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yvrB [2019-02-01 12:37:58]
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yvrB [2019-02-01 12:37:58]

ABC transporter (ATP binding domain), similar to iron permease
locus
BSU33170
pI
11.07
mw
37.34 kDa
protein length
353 aa Sequence Blast
gene length
1062 bp Sequence Blast
function
unknown
product
ABC transporter (ATP binding domain)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.7|Uptake of cofactors]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.13|Biosynthesis/ acquisition of cobalamine (B12))]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,402,469 3,403,530

    The protein

    Structure

  • [PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuC shares 40% identity, 71% similarity with YvrB, [Pubmed|25402482]

    • Expression and Regulation

    Operons

    genes
    [gene|C76265F521D9A153F28AC6BACD935CC20DEA5D9C|yvrC]-[gene|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC|yvrB]-[gene|128EBAE9C14C7BB75173DF912853A6FCE86ABCE4|yvrA]-[gene|468D9141EAC78556C9F6C564875F70EC43E60C1C|yvqK]

    regulatory mechanism

  • [regulon|B12 riboswitch|B12 riboswitch]: termination, upon binding of B12 [Pubmed|14704351], in [regulon|B12 riboswitch|B12 riboswitch]

    • regulation

  • expression is decreased in the presence of cobalamin (vitamin B12) ([SW|B12 riboswitch]) [Pubmed|14704351]
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    Biological materials

    Mutant

  • MGNA-B044 (yvrB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1043 NBRP B. subtilis, Japan]
  • BKE33170 ([gene|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC|yvrB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ACCAATGATATATGCGGCAT, downstream forward: _UP4_CATCGCGGGGGGAGAAGCTT
  • BKK33170 ([gene|1DC4A3D7E93677B0EAD15F43C80E50FD98527EBC|yvrB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_ACCAATGATATATGCGGCAT, downstream forward: _UP4_CATCGCGGGGGGAGAAGCTT

    • References

  • 10092453,25402482,14704351